이름
김현수
(Hyunsoo Kim)
전공
단백체학 및 생물정보학
연락처
연구실
생명시스템과학대학 113호
경력사항
2021.03.01 ~ 현재까지: 충남대학교 생명시스템과학대학 생명정보융합학과, 조교수 2021.03.01 ~ 현재까지: Scripps Research, Molecular Medicine (미국), 전문과학협력자 2019.03.04 ~ 2021.01.29: Scripps Research, Molecular Medicine (미국), 박사후연구원 2015.06.01 ~ 2019.02.28: 서울대학교 의학연구원 의용생체공학연구소, 선임연구원 2015.03.15 ~ 2015.05.31: 서울대학교 의학연구원 의용생체공학연구소, 연수연구원 2015.03.01 ~ 2019.02.28: 서울대학교 의과대학 의과학과, 박사후연구원
단백체정보학 실험실 (Proteomic Informatics Lab.)
1. 단일세포 다차원 단백체 기반 펩타이드 약물 발굴 (Single-Cell Multidimensional Proteome for Peptide Drug Discovery) : 단일세포 다차원 단백체 데이터를 기반으로 핵심 단백질 간 네트워크 변화를 확인하여 치료 표적으로의 기능을 규명하고 이를 제어하는 mimic 펩타이드의 약물 발굴과 유효성 검증 (Drug discovery and validation of mimic peptides that control the therapeutic target function of key protein-protein interactions based on single cell structural proteomics). 2. 단백체 빅데이터와 인공지능 기반 임상 바이오마커 발굴 (Clinical Biomarker Discovery through Proteomics and AI-guiding) : LC-MS 기반의 단백체 빅데이터와 머신러닝을 이용하여 임상 바이오마커 발굴과 질병 진단 모델 개발 (Discovering clinical biomarkers and developing disease diagnosis models using machine learning on liquid chromatography and mass spectrometry-based proteome big data). 3. 액체크로마토그래피-질량분석기 기반 체외&동반 진단법 개발 (In Vitro & Companion Diagnostic LC-MS Assay in Clinical Laboratory) : LC-MS 기반으로 기존 분석법의 분석적인 성능을 개량하고 검증해서 국제적으로 표준화된 체외진단법과 동반진단법 신의료기술 개발 (Improving and verifying analytical performance based on LC-MS assays and developing internationally standardized in vitro and companion diagnostic assays with new health technology). 4. 다중오믹스 바이오 빅데이터 분석 시스템 개발 (Multi-Omic Bio Big Data Analytics Development) : 인공지능 기반으로 다중 오믹스 빅 데이터 통합 및 분석 도구 개발과 임상 현장에서 의사 결정에 도움을 줄 수 있는 시스템 및 소프트웨어 개발 (Developing a tool that can help the clinician’s decision-making process in hospitals using multi-omic bio big data and artificial intelligence algorithms).
논문 (Publication)
026. Misol Do*, Hyunsoo Kim*, Injoon Yeo, Jihyeon Lee, In Ae Park, Han Suk Ryu, Youngsoo Kim. Clinical application of multiple reaction monitoring-mass spectrometry to human epidermal growth factor receptor 2 measurements as a potential diagnostic tool for breast cancer therapy. Clinical Chemistry (ISSN: 0009-9147), 66 (10), 1339-1348 (2020-10-01) 025. Yoseop Kim, Injoon Yeo, Hyunsoo Kim, Minsoo Son, Youngsoo Kim. Preparation of Tissue Samples for Large-scale Quantitative Mass Spectrometric Analysis. Biotechnology and Bioprocess Engineering (ISSN: 1226-8372), 25 (4), 551-561 (2020/07/22) 024. JaeNyeon Kim*, Injoon Yeo*, Hyunsoo Kim*, Areum Sohn, Yosub Kim, Youngsoo Kim. Web portal for analytical validation of MRM-MS assay abided with integrative multinational guidelines. Scientific Reports (ISSN: 2045-2322) 10 (1), 1-9 (2020/07/02) 023. Injoon Yeo*, Gi-Ae Kim*, Hyunsoo Kim*, Ji Hyeon Lee, Areum Sohn, Geum-Youn Gwak, Jeong-Hoon Lee, Young-Suk Lim, Youngsoo Kim. Proteome Multimarker Panel with Multiple Reaction Monitoring-Mass Spectrometry for Early Detection of Hepatocellular Carcinoma. Hepatology Communications (ISSN: 2471-254X) 4 (5), 753-768 (2020/03/13) 022. Hyunsoo Kim, Yoseop Kim, Buhm Han, Jin-Young Jang, Youngsoo Kim. Clinically Applicable Deep Learning Algorithm Using Quantitative Proteomics Data. Journal of Proteome Research (ISSN: 1535-3893). 18 (8), 3195-3202 (2019/07/17) 021. Jihyeon Lee*, Hyunsoo Kim*, Areum Sohn, Injoon Yeo, Youngsoo Kim. Cost-Effective Automated Preparation of Serum Samples for Reproducible Quantitative Clinical Proteomics. Journal of Proteome Research (ISSN: 1535-3893). 18 (5), 2337-2345 (2019/04/15) 020. Minsoo Son*, Hyunsoo Kim*, Injoon Yeo, Yosub Kim, Areum Sohn, Youngsoo Kim. Method validation by CPTAC guidelines for multi-protein marker assays using multiple reaction monitoring-mass spectrometry. Biotechnology and Bioprocess Engineering (ISSN: 1226-8372). 24 (2), 343-358 (2019/03/01) 019. Jong su Jun, Jungsoo Gim, Yongkang Kim, Hyunsoo Kim, Su Jong Yu, Injun Yeo, Jiyoung Park, Jeong-Ju Yoo, Young Youn Cho, Dong Hyeon Lee, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Seungyeoun Lee, Jung-Hwan Yoon, Youngsoo Kim, Taesung Park. Analysis of significant protein abundance from multiple reaction-monitoring data. BMC Systems Biology (ISSN: 1752-0509). 12 (9), 123 (2018/12/31) 018. Hyunsoo Kim, Areum Sohn, Injun Yeo, Su Jong Yu, Jung-Hwan Yoon, Youngsoo Kim. Clinical Assay for AFP-L3 by Using Multiple Reaction Monitoring-Mass Spectrometry for Diagnosing Hepatocellular Carcinoma. Clinical Chemistry (ISSN: 0009-9147). 64 (8), 1230-1238 (2018/08/01) 017. Areum Sohn*, Hyunsoo Kim*, Injun Yeo, Yoseop Kim, Minsoo Son, Su Jong Yu, Jung-Hwan Yoon, Youngsoo Kim. Fully validated SRM-MS-based method for absolute quantification of PIVKA-II in human serum: Clinical applications for patients with HCC. Journal of Pharmaceutical and Biomedical Analysis (ISSN: 0731-7085). 156, 142-146 (2018/07/15) 016. Misol Do, Dohyun Han, Joseph Injae Wang, Hyunsoo Kim, Wooil Kwon, SungHyo Park, Youngmin Han, Jin-Young Jang, Youngsoo Kim. Quantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms. Clinical proteomics (ISSN: 1542-6416). 15 (1), 17 (2018/04/18) 015. Jiyoung Park, Yonghwan Choi, Junghyun Namkung, Sung Gon Yi, Hyunsoo Kim, Jiyoung Yu, Yongkang Kim, Min-Seok Kwon, Wooil Kwon, Do-Youn Oh, Sun-Whe Kim, Seung-Yong Jeong, Wonshik Han, Kyu Eun Lee, Jin Seok Heo, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Chang Moo Kang, Woo Jin Lee, Seungyeoun Lee, Sangjo Han, Taesung Park, Jin-Young Jang, Youngsoo Kim. Diagnostic performance enhancement of pancreatic cancer using proteomic multimarker panel. Oncotarget (ISSN: 1949-2553). 8 (54), 93117-93130 (2018/01/12) 014. Hyunsoo Kim, Joonho Park, Joseph I. Wang, Youngsoo Kim. Recent advances in proteomic profiling of pancreatic ductal adenocarcinoma (PDAC) and the road ahead. Expert Review of Proteomics (ISSN: 1478-9450). 14 (11), 963-971 (2017/11/02) 013. Jongmin Woo, Dohyun Han, Joseph Wang, Joonho Park, Hyunsoo Kim, Youngsoo Kim. Quantitative proteomics reveals temporal proteomic changes in signaling pathways during BV2 microglial cell activation. Journal of Proteome Research (ISSN: 1535-3893). 16 (9), 3419-3432 (2017/09/01) 012. Hyunsoo Kim, JiYoung Park, Yongkang Kim, A-Reum Sohn, Injun Yeo, Su Jong Yu, Jung-Hwan Yoon, Taesung Park, Youngsoo Kim. Serum fibronectin distinguishes the early stages of hepatocellular carcinoma. Scientific Reports (ISSN: 2045-2322). 7 (1), 9449 (2017/08/25) 011. Hyunsoo Kim, Su Jong Yu, Injun Yeo, Young Youn Cho, Dong Hyeon Lee, Yuri Cho, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Sungyoung Lee, Jongsoo Jun, Taesung Park, Jung-Hwan Yoon, Youngsoo Kim. Prediction of Response to Sorafenib in Hepatocellular Carcinoma: A Marker Panel by Multiple Reaction Monitoring-Mass Spectrometry. Molecular & Cellular Proteomics (ISSN: 1535-9476). 16 (7), 1312-1323 (2017/07/01) 010. Areum Sohn*, Hyunsoo Kim*, Su Jong Yu, Jung-Hwan Yoon, Youngsoo Kim. A quantitative analytical method for PIVKA-II using multiple reaction monitoring-mass spectrometry for early diagnosis of hepatocellular carcinoma. Analytical and Bioanalytical Chemistry (ISSN: 1618-264). 409 (11), 2829-2838 (2017/04/01) 009. Su Jong Yu*, Hyunsoo Kim*, Hophil Min, Areum Sohn, Young Youn Cho, Jeong-Ju Yoo, Dong Hyeon Lee, Eun Ju Cho, Jeong-Hoon Lee, Jungsoo Gim, Taesung Park, Yoon Jun Kim, Chung Yong Kim, Jung-Hwan Yoon, Youngsoo Kim. Targeted proteomics predict a sustained complete-response after transarterial chemoembolization and clinical outcomes in patients with hepatocellular carcinoma: a prospective cohort study. Journal of Proteome Research (ISSN: 1535-3893). 16 (3), 1239-1248 (2017/03/03) 008. Joo Young Shin, Areum Sohn, Hyunsoo Kim, Youngsoo Kim, Hyeong Gon Yu. Carboxymethyl-Lysine-Modified Plasma Proteins in Age-related Macular Degeneration. Biotechnology and Bioprocess Engineering (ISSN: 1226-8372). 22 (1), 52-59 (2017/02/01) 007. Yongkang Kim, Min-Seok Kwon, Yonghwan Choi, Sung Gon Yi, Junghyun Namkung, Sangjo Han, Wooil Kwon, Hyunsoo Kim, Sun Whe Kim, Jin-Young Jang, Youngsoo Kim, Seungyeoun Lee, Taesung Park. Comparative studies for developing protein based cancer prediction model to maximize the ROC-AUC with various variable selection methods. International Journal of Data Mining and Bioinformatics (ISSN: 1748-5673). 16 (1), 64-76 (2016/07/01) 006. Yikwon Kim, MeeJoo Kang, Dohyun Han, Hyunsoo Kim, KyoungBun Lee, Sun-Whe Kim, Yongkang Kim, Taesung Park, Jin-Young Jang, Youngsoo Kim. Biomarker Development for Intraductal Papillary Mucinous Neoplasms Using Multiple Reaction Monitoring Mass Spectrometry. Journal of Proteome Research (ISSN: 1535-3893). 15 (1), 100-113 (2016/01/04) 005. Hyunsoo Kim, Kyunggon Kim, Jonghwa Jin, Jiyoung Park, Su Jong Yu, Jung-Hwan Yoon, Youngsoo Kim. Measurement of Glycosylated Alpha-Fetoprotein Improves Diagnostic Power over the Native Form in Hepatocellular Carcinoma. PLoS ONE (ISSN: 1932-6203). 9 (10), e110366 (2014/10/13) 004. Jiyoung Yu, Kyunggon Kim, MeeJoo Kang, Hyunsoo Kim, Sun Whe Kim, Jin-Young Jang, Youngsoo Kim. Development of Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma Using Multiple Reaction Monitoring. Biotechnology and Bioprocess Engineering (ISSN: 1226-8372). 18 (5), 1038-1047 (2013/09/01) 003. Hyunsoo Kim, Kyunggon Kim, Su Jong Yu, Eun Sun Jang, Jiyoung Yu, Geunhee Cho, Jung-Hwan Yoon, Youngsoo Kim. Development of Biomarkers for Screening Hepatocellular Carcinoma Using Global Data Mining and Multiple Reaction Monitoring. PLoS ONE (ISSN: 1932-6203). 8 (5), e63468 (2013/05/22) 002. Dohyun Han, Sungyoon Moon, Hyunsoo Kim, Sung-E Choi, Soo-Jin Lee, Kyong Soo Park, Heesook Jun, Yup Kang, Youngsoo Kim. Detection of Differential Proteomes Associated with the Development of Type 2 Diabetes in the Zucker Rat Model Using the iTRAQ Technique. Journal of Proteome Research (ISSN: 1535-3893). 10 (2), 564-577 (2011/02/04) 001. Kyunggon Kim, Jiyoung Yu, Hophil Min, Hyunsoo Kim, Byungwook Kim, Hyeong Gon Yu, Youngsoo Kim. Online monitoring of immunoaffinity-based depletion of high-abundance blood proteins by UV spectrophotometry using enhanced green fluorescence protein and FITC-labeled human serum albumin. Proteome Science (ISSN: 1477-5956). 8 (1), 62 (2010/12/01)
특허 & 저작권 (Patent & Copyright)
024. 김현수, 박종함, 손아름. 표적 단백체 기반 단백질 상호작용체 분석 툴. 대한민국, C-2022-042073 (2022/10/31) 023. 김영수, 유한석, 김현수, 도미솔. 유방암 샘플에서 질량분석법 의한 허2 정량 방법 및 이를 이용한 허2 상태 스코어링. 대한민국, 10-20190093135 (2021/02/23) 022. 김영수, 임영석, 김현수, 여인준. 간암 고위험군의 간암 발병 모니터링 또는 진단용 바이오마커 및 그 용도. 대한민국, 10-2116178 (2020/05/21) 021. 김영수, 임영석, 김영수, 유한석, 김현수, 도미솔. Development of Multiplex Assay for HER2 proteins & Companion Diagnostics Using Mass Spectrometry with Breast Cancer FFPE (Formalin-Fixed, Paraffin-Embedded) Tissue Specimens. PCT, KR2020/003138 (2020/03/06) 020. 김영수, 윤정환, 김현수, 김경곤, 진종화. Cancer marker screening method through detection of deglycosylation of glycoprotein and hepatocellular cancer marker. 영국, 3-035-058 (2019/09/04) 019. 김영수, 윤정환, 김현수, 김경곤, 진종화. Cancer marker screening method through detection of deglycosylation of glycoprotein and hepatocellular cancer marker. 프랑스, 3-035-058 (2019/09/04) 018. 김영수, 윤정환, 김현수, 김경곤, 진종화. Cancer marker screening method through detection of deglycosylation of glycoprotein and hepatocellular cancer marker. 독일, 3-035-058 (2019/09/04) 017. 김영수, 김현수, 김요섭. 췌장암 진단용 바이오마커 및 그 용도. 대한민국, 10-20190082497 (2019/07/09) 016. 김영수, 김현수, 김재년. 생체시료 분석법 검증 포털 Version 1.0 (http://pnbvalid.snu.ac.kr). 대한민국, C-2019-004106 (2019/02/13) 015. 김영수, 윤정환, 김현수, 진종화. Biomarker for diagnosing liver cancer. 프랑스, 2-977-760 (2018/05/30) 014. 김영수, 윤정환, 김현수, 진종화. Biomarker for diagnosing liver cancer. 독일, 2-977-760 (2018/05/30) 013. 김영수, 윤정환, 김현수, 민호필. 간암 화학 색전술 치료 예후 예측을 위한 바이오마커 및 그 용도. 대한민국, 10-1859812 (2018/05/14) 012. 김영수, 임영석, 김현수, 여인준. Biomarkers for predicting the risk of developing liver cancer using blood based on Multiple Reaction Monitoring. PCT, KR2018/005353 (2018/05/10) 011. 김영수, 윤정환, 김현수, 김경곤, 진종화. Method for diagnosing cancer through detection of deglycosylation of glycoprotein. 미국, 9,938,561 (2018/04/10) 010. 김영수, 윤정환, 김현수, 여인준. 간암 표적치료제 반응 예측용 바이오마커 및 그 용도. 대한민국, 10-1832039 (2018/02/19) 009. 김영수, 윤정환, 김현수, 손아름. 다중동시정량법을 이용한 PIVKAII의 정량 또는 검출 방법. 대한민국, 10-1796874 (2017/11/06) 008. 김영수, 윤정환, 김현수. 간암 조기 진단용 바이오마커 및 그 용도. 대한민국, 10-1788414 (2017/10/13) 007. 김영수, 윤정환, 김현수. Biomarker for diagnosis of hepatoma and use thereof. 중국, 201580067274.5 (2017/08/29) 006. 김영수, 윤정환, 김현수. Biomarker for diagnosis of hepatoma and use thereof. 유럽, 15868405 (2017/07/11) 005. 김영수, 임영석, 김현수, 여인준 MRM 분석 기반의 간암의 발병 또는 위험도 예측용 다중 혈액 단백질 바이오 마커. 대한민국, 10-2017-0058007 (2017/05/10) 004. 김영수, 윤정환, 김현수, 여인준. Biomarkers to predict target drug efficacy for hepatocellular carcinoma and its use. PCT, KR2015/013481 (2015/12/10) 003. 김영수, 윤정환, 김현수, 김경곤, 진종화. 당단백질의 탈당화 검출을 통한 암 마커 스크리닝 방법 및 간세포암 마커. 대한민국, 10-1527283 (2015/06/02) 002. 김영수, 윤정환, 김현수, 진종화. 간암 진단용 바이오 마커. 대한민국, 10-1520615 (2015/05/11) 001. 김영수, 윤정환, 김현수, 김경곤, 진종화. 당단백질의 탈당화 검출을 통한 암 진단 방법. 대한민국, 10-1520614 (2015/05/11)